Resolute® BioSC Forecast is really an special simulation and optimization computer software for the event of intensified chromatography processes, enabling researchers to simply switch from batch to some streamlined constant process, with none prior skilled information.
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The stationary stage is hydrophobic, Whilst the versatile phase can be a polar liquid, for example h2o-methanol or acetonitrile mixes. It is predicated around the hydrophobic collaboration rule, which states the more nonpolar the compound, the greater It will probably be retained.
UV detectors reply only to These substances that take up UV mild within the wavelength from the source gentle. A fantastic quite a few compounds take in mild inside the UV assortment (180-350 nm) which include substances obtaining a number of double bonds and substances possessing unshared electrons.
Connected or semi-linked downstream processing supplies substantial enhancements to productiveness, Value, timelines, and facility footprint. Our versatile portfolio lets you end up picking an intensification tactic that aligns with your one of a kind system aims.
An increase in counter ion (with regard into the practical groups in resins) focus decreases the retention time, mainly because it produces a strong Levels of competition With all the solute ions. A decrease in pH cuts down the retention time in cation exchange though a rise in pH lowers the retention time in anion Trade.
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Resolute® BioSC Pilot can hook up several steps for instance chromatography, viral inactivation and in-line buffer preparing. The chaining of multiple procedures leads to a streamlined and intensified procedure.
The solvent reservoir check here holds get more info the cell stage and is often Outfitted with a degassing program to get rid of any dissolved gases which will interfere While using the analysis.
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Be a part of Sartorius as we examine how you can transfer a standalone batch mAb chromatography approach to the linked DSP.
HPLC techniques help in the identification and quantification of such substances, sustaining customer security and regulatory compliance.
Be part of Sartorius as we investigate the way to transfer a standalone batch mAb chromatography approach to the connected DSP.
Be a part of Sartorius as we discover how you can transfer a standalone batch mAb chromatography approach to a linked DSP.